Peptide Database

Peptide NameVpr 69-83

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition

Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition

Enzyme modulation ▸ Enzyme inhibition ▸ Reverse transcriptase inhibition

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC81H126N26O18S

DescriptionStandard

        FIHFRIGCQHSRIGI
    

Molecular Weight1784.10 Da

Isoelectric Point (pI)10.35

Net Charge (pH 7.0)1.92

Net Charge (pH 7.4) 1.61

Charge Density (pH 7.0) 0.1283

GRAVY Index0.37

Hydrophobic Moment 0.57

Boman Index0.15

Instability Index12.80

Aliphatic Index 104.00

Aromaticity 0.1333

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 715.20

LogP -5.24

H-bond Donors 27.0

H-bond Acceptors 23.0

Rotatable Bonds 58.0

Heavy Atoms 126.0

Ring Count 4.0

Amide Bonds 15.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0419781 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Replication inhibition

Targetinhibition of disintegration catalyzed by integrase

Activity200 μM

MethodIC50

Half-LifeMammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min

PaperInhibition of the activities of reverse transcriptase and integrase of human immunodeficiency virus type-1 by peptides derived from the homologous viral protein R (Vpr). | Gleenberg IO, Herschhorn A, Hizi A. | J Mol Biol. 2007 Jun 22;369(5):1230-43. | DOI:10.1016/j.jmb.2007.03.073 | PMID:17490682 PMID17490682 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17490682/

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