‹ ›
MYP_004703
← PREVIOUS NEXT → BACK
Basic Information
Vpr 69-83
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Reverse transcriptase inhibition
Standard
15 amino acids
C81H126N26O18S
Standard
Sequence
FIHFRIGCQHSRIGI
Physicochemical Analysis
1784.10 Da
10.35
1.92
1.61
0.1283
0.37
0.57
0.15
12.80
104.00
0.1333
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
715.20
-5.24
27.0
23.0
58.0
126.0
4.0
15.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0269916 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
inhibit the activity of Rnase H
IC50
PMID17490682 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17490682/
RECORD: Rec_0276844 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
inhibit the activity of DNA-dependent DNA polymerase
IC50
PMID17490682 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17490682/
RECORD: Rec_0306379 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Inhibition of 3′-end processing catalyzed by integrase
IC50
PMID17490682 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17490682/
RECORD: Rec_0338501 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Replication inhibition
inhibit the activity of DNA-dependent DNA polymerase
200 μM
IC50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperInhibition of the activities of reverse transcriptase and integrase of human immunodeficiency virus type-1 by peptides derived from the homologous viral protein R (Vpr). | Gleenberg IO, Herschhorn A, Hizi A. | J Mol Biol. 2007 Jun 22;369(5):1230-43. | DOI:10.1016/j.jmb.2007.03.073 | PMID:17490682 PMID17490682 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17490682/
RECORD: Rec_0343475 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Replication inhibition
inhibit the activity of Rnase H
200 μM
IC50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperInhibition of the activities of reverse transcriptase and integrase of human immunodeficiency virus type-1 by peptides derived from the homologous viral protein R (Vpr). | Gleenberg IO, Herschhorn A, Hizi A. | J Mol Biol. 2007 Jun 22;369(5):1230-43. | DOI:10.1016/j.jmb.2007.03.073 | PMID:17490682 PMID17490682 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17490682/
FIRST PREV 1 2 3 4 NEXT LAST
Showing 5 records on this page · Page 2 of 4