Peptide Database

Peptide NameMT-Sifuvirtide

Function Ontology

Antiviral

Standard StatusStandard

Sequence Length37 amino acids

Chemical FormulaC207H318N60O72S

DescriptionStandard

        MTWETWEREIENYTRQIYRILEESQEQQDRNERDLLE
    

Molecular Weight4831.16 Da

Isoelectric Point (pI)4.41

Net Charge (pH 7.0)-6.47

Net Charge (pH 7.4) -6.71

Charge Density (pH 7.0) -0.1748

GRAVY Index-1.69

Hydrophobic Moment 0.85

Boman Index-0.44

Instability Index62.79

Aliphatic Index 63.24

Aromaticity 0.1081

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 13980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2242.22

LogP -20.78

H-bond Donors 78.0

H-bond Acceptors 67.0

Rotatable Bonds 167.0

Heavy Atoms 340.0

Ring Count 6.0

Amide Bonds 42.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0058601 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral

TargetHIV-1 NL4-3

Activity0.51±0.21 nM

MethodIC50 (HIV-1 infection inhibition)

RECORD: Rec_0431450 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHIV gp41 fusion inhibitor

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Fusion inhibitor Protein-binding Structural binding

TargetHIV-1 envelope glycoprotein gp160 (gp41 region)

MethodX-ray crystallography (protein-peptide complex structure)