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MYP_004663
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Basic Information
Brevinin-1AUa
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
24 amino acids
C122H206N28O27S2
Standard
Sequence
FLPILAGLAAKLVPKVFCSITKKC
Physicochemical Analysis
2561.24 Da
9.70
3.74
3.50
0.1557
1.16
0.61
0.35
26.58
134.17
0.0833
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
859.58
-2.93
31.0
33.0
83.0
179.0
4.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0008210 VERIFIED: YES
Provenance & Taxonomy
Rana aurora aurora [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa ATCC 27853
25 μM
MIC
PMID15325526 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15325526/
RECORD: Rec_0048298 VERIFIED: YES
Provenance & Taxonomy
Rana aurora aurora [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Antifungal
Staphylococcus aureus
3 μM
MIC
PaperHost-defense peptides isolated from the skin secretions of the Northern red-legged frog Rana aurora aurora.
RECORD: Rec_0053005 VERIFIED: YES
Provenance & Taxonomy
Rana aurora [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus
3 μM
MIC
PMID15325526 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15325526/
RECORD: Rec_0072995 VERIFIED: YES
Provenance & Taxonomy
Rana aurora aurora [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli
13 μM
MIC
PMID15325526 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15325526/
RECORD: Rec_0083307 VERIFIED: YES
Provenance & Taxonomy
Rana aurora [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
18-24
Bio-Activity Profile
Antimicrobial Antifungal
PaperJ.M. Conlon et al. / Developmental and Comparative Immunology 29 (2005) 83-90. Host-defense peptides isolated from the skin secretions of the Northern red-legged frog Rana aurora aurora
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