Peptide Database

Peptide NameC18-cp3c

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza A ▸ Anti-H1N1

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor

Enzyme modulation ▸ Enzyme inhibition ▸ Binding inhibition

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC67H109N19O26S

DescriptionStandard

        AETVESCLAKPHTEN
    

Molecular Weight1628.76 Da

Isoelectric Point (pI)4.75

Net Charge (pH 7.0)-2.12

Net Charge (pH 7.4) -2.38

Charge Density (pH 7.0) -0.1413

GRAVY Index-0.72

Hydrophobic Moment 0.38

Boman Index-0.09

Instability Index59.53

Aliphatic Index 58.67

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 732.31

LogP -9.32

H-bond Donors 25.0

H-bond Acceptors 26.0

Rotatable Bonds 52.0

Heavy Atoms 113.0

Ring Count 2.0

Amide Bonds 15.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0259167 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAlkylated(C18)

C-TermAmidation

Other ModsAlkylated(C18)

Bio-Activity Profile

Function

Antiviral Anti-H3N2 Binding inhibition

TargetH3N2 (A/Aichi/2/68)

Activity100 μM

MethodIC50

Half-LifeMammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h

PaperInhibition of influenza virus infections by sialylgalactose-binding peptides selected from a phage library. | Matsubara T, Sumi M, Kubota H, Taki T, Okahata Y, Sato T. | J Med Chem. 2009 Jul 23;52(14):4247-56. | DOI:10.1021/jm801570y | PMID:19558186 PMID19558186 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19558186/

RECORD: Rec_0289788 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

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