Peptide Database

Peptide NameSLAY-screened peptide P4719

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC102H145N27O29S

DescriptionStandard

        APVRANSFYLTWPPSDHPSC
    

Molecular Weight2245.47 Da

Isoelectric Point (pI)6.78

Net Charge (pH 7.0)-0.13

Net Charge (pH 7.4) -0.38

Charge Density (pH 7.0) -0.0063

GRAVY Index-0.47

Hydrophobic Moment 0.23

Boman Index0.06

Instability Index81.30

Aliphatic Index 44.00

Aromaticity 0.1500

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 868.97

LogP -8.84

H-bond Donors 30.0

H-bond Acceptors 31.0

Rotatable Bonds 59.0

Heavy Atoms 159.0

Ring Count 9.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0300787 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/