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MYP_004499
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Basic Information
Clavanin E
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Standard
23 amino acids
C130H192N34O26
Standard
Sequence
LFKLLGKIIHHVGNFVHGFSHVF
Physicochemical Analysis
2647.13 Da
10.00
2.11
1.70
0.0916
0.79
0.68
0.43
-21.10
122.61
0.1739
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
933.60
-2.88
32.0
32.0
85.0
190.0
8.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0064922 VERIFIED: YES
Provenance & Taxonomy
Styela clava [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal
yeast Candida albicans
PaperPubMed PMID: 9237689 PMID9237689 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9237689/
RECORD: Rec_0077400 VERIFIED: YES
Provenance & Taxonomy
Styela clava [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Staphylococcus aureus ATCC 43300 MRSA was also observed
64 μg/mL
MIC
PapercDNA cloning of Clavanins: antimicrobial peptides of tunicate hemocytes.
RECORD: Rec_0238692 VERIFIED: YES
Provenance & Taxonomy
Sea squirt [Animal]; Animalia [Animal]
33208; 33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID9001389 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9001389/
RECORD: Rec_0309734 VERIFIED: YES
Provenance & Taxonomy
Styela clava [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
The MIC was essentially the same for Cu or Zn complex
16-32 μg/mL
MIC
PapercDNA cloning of Clavanins: antimicrobial peptides of tunicate hemocytes.
RECORD: Rec_0325516 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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