Peptide Database

Peptide NameSLAY-screened peptide P4578

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC107H158N28O31S

DescriptionStandard

        PPRSLRDDLSHCDVPAYYFI
    

Molecular Weight2364.63 Da

Isoelectric Point (pI)5.30

Net Charge (pH 7.0)-0.96

Net Charge (pH 7.4) -1.09

Charge Density (pH 7.0) -0.0481

GRAVY Index-0.41

Hydrophobic Moment 0.54

Boman Index-0.05

Instability Index82.02

Aliphatic Index 78.00

Aromaticity 0.1500

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 929.95

LogP -7.17

H-bond Donors 34.0

H-bond Acceptors 32.0

Rotatable Bonds 69.0

Heavy Atoms 167.0

Ring Count 7.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0382314 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/