Peptide Database

Peptide NameCrotamine (Crt) (Myotoxin)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length65 amino acids

Chemical FormulaC346H530N90O82S8

DescriptionStandard

        MKILYLLFAFLFLAFLSEPGNAYKQCHKKGGHCFPKEKICLPPSSDFGKMDCRWRWKCCKKGSGK
    

Molecular Weight7518.98 Da

Isoelectric Point (pI)9.54

Net Charge (pH 7.0)8.61

Net Charge (pH 7.4) 8.18

Charge Density (pH 7.0) 0.1325

GRAVY Index-0.29

Hydrophobic Moment 0.46

Boman Index-0.00

Instability Index61.88

Aliphatic Index 58.62

Aromaticity 0.1538

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 14355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2746.28

LogP -17.73

H-bond Donors 101.0

H-bond Acceptors 101.0

Rotatable Bonds 250.0

Heavy Atoms 526.0

Ring Count 18.0

Amide Bonds 66.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0127573 VERIFIED: YES

Provenance & Taxonomy

OrganismCrotalus durissus terrificus [Animal]

FamilyCrotamine-myotoxin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Toxin Non-hemolytic

TargetBacillus subtilis (Gram-positive)

RECORD: Rec_0171925 VERIFIED: YES

Provenance & Taxonomy

OrganismCrotalus durissus terrificus [Animal]

FamilyCrotamine-myotoxin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Toxin Non-hemolytic

TargetTrichosporon spp.

RECORD: Rec_0181599 VERIFIED: YES

Provenance & Taxonomy

OrganismCrotalus durissus terrificus [Animal]

FamilyCrotamine-myotoxin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Toxin Non-hemolytic

TargetEscherichia coli (Gram-negative)

RECORD: Rec_0413646 VERIFIED: YES

Provenance & Taxonomy

OrganismCrotalus durissus terrificus [Animal]

FamilyCrotamine-myotoxin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Toxin Non-hemolytic

TargetCandida