Peptide Database

Peptide NameFIV Egp (732-766)

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Anti-Retrovirus ▸ Anti-Lentivirus ▸ Anti-FIV

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard StatusStandard

Sequence Length35 amino acids

Chemical FormulaC188H292N50O59S

DescriptionStandard

        LGEWYNQTKDLQQKFYEIIMDIEQNNVQGKKGIQQ
    

Molecular Weight4228.69 Da

Isoelectric Point (pI)4.94

Net Charge (pH 7.0)-1.24

Net Charge (pH 7.4) -1.45

Charge Density (pH 7.0) -0.0353

GRAVY Index-1.11

Hydrophobic Moment 0.59

Boman Index-0.14

Instability Index44.87

Aliphatic Index 75.14

Aromaticity 0.1143

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1850.68

LogP -16.75

H-bond Donors 59.0

H-bond Acceptors 59.0

Rotatable Bonds 150.0

Heavy Atoms 298.0

Ring Count 5.0

Amide Bonds 44.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0251286 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Entry inhibition

TargetFeline immunodeficiency virus (FIV); FCD4-E cells

Activity0.177 μM

MethodEC90

Half-LifeMammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min

PaperC-Terminal gp40 peptide analogs inhibit feline immunodeficiency virus: cell fusion and virus spread. | Medinas RJ, Lambert DM, Tompkins WA. | J Virol. 2002 Sep;76(18):9079-86. | DOI:10.1128/jvi.76.18.9079-9086.2002 | PMID:12186891 PMID12186891 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12186891/

RECORD: Rec_0269173 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-FIV Fusion inhibition

TargetFeline immunodeficiency virus (FIV); FIV/CrFK cells; HeLa cells

Activity0.05 μM

MethodEC50

Half-LifeMammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min

PaperC-Terminal gp40 peptide analogs inhibit feline immunodeficiency virus: cell fusion and virus spread. | Medinas RJ, Lambert DM, Tompkins WA. | J Virol. 2002 Sep;76(18):9079-86. | DOI:10.1128/jvi.76.18.9079-9086.2002 | PMID:12186891 PMID12186891 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12186891/

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