Peptide Database

Peptide NameOpistoporin-4 (Non-disulfide-bridged peptides 3.7, NDBP-3.7; Arthropods, animals)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length44 amino acids

Chemical FormulaC217H356N60O62

DescriptionStandard

        GKVWDWIKKTAKDVLNSDVAKQLKNKALNAAKNFVAEKIGATPS
    

Molecular Weight4797.51 Da

Isoelectric Point (pI)9.90

Net Charge (pH 7.0)4.76

Net Charge (pH 7.4) 4.54

Charge Density (pH 7.0) 0.1081

GRAVY Index-0.48

Hydrophobic Moment 0.72

Boman Index-0.07

Instability Index9.91

Aliphatic Index 86.59

Aromaticity 0.0682

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2017.16

LogP -19.34

H-bond Donors 68.0

H-bond Acceptors 67.0

Rotatable Bonds 166.0

Heavy Atoms 339.0

Ring Count 6.0

Amide Bonds 48.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0118378 VERIFIED: YES

Provenance & Taxonomy

OrganismOpistophthalmus carinatus [Animal]

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetAlso has antifungal activity

RECORD: Rec_0174977 VERIFIED: NO

Provenance & Taxonomy

OrganismOpistophthalmus carinatus [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hemolytic

Targethuman RBCs

MethodHemolysis

RECORD: Rec_0292229 VERIFIED: YES

Provenance & Taxonomy

OrganismOpistophthalmus carinatus [Animal]

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

Targetstrong antibacterial activity against Gram-negative bacteria but is less active against Gram-positive bacteria

RECORD: Rec_0398955 VERIFIED: YES

Provenance & Taxonomy

OrganismOpistophthalmus carinatus [Animal]

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic

Targethuman erythrocytes