Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length456 amino acids

Chemical FormulaC2311H3659N625O648S8

DescriptionStandard

        TNPGFVVRITQAGLDYAHQHGITILEKELAQLKLPDMSGDSRVGRVGKVRYELSRLRLRDFHLPYSRITPISNVGLQVSISNAFAELDGDWRVKFLFVRDHGSFDLKAENVYIKISLRLGSDAAGKPTVSTSECSARISKVRVLFSGRLGWLYNLFHGAIESRFRKILEDKICDIVDKSVRNELQKFVQTLPVTARIDAKTGIDYSLVAAPRATAQFLDAGLKGEFYSLAHRSTVPFSPLPLAFPSDHDRMVYFGASSYFFNTAGIAYHEAGALVFEITEDMIPKDSRFSLDTSLFSVFIPQLEEMYPNMPVKFRLSTPTAPFLTIGPGGISLNPIVDAQAYAILPNSSLAPLFLLSLVRNVSAVINVRSDRIVGSLDVGRIRLSLKDSAVGTFEVRTIQSLMNILTSKILLPRLNARLDEGFPLPLLDRIQLSNILVRFYQNFLLLGADVHFQPR
    

Molecular Weight50823.09 Da

Isoelectric Point (pI)9.34

Net Charge (pH 7.0)8.21

Net Charge (pH 7.4) 7.44

Charge Density (pH 7.0) 0.0180

GRAVY Index0.08

Hydrophobic Moment 0.79

Boman Index0.08

Instability Index33.23

Aliphatic Index 104.98

Aromaticity 0.0965

Extinction Coeff. Reduced 30370.00

Extinction Coeff. Oxidized 30495.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0105669 VERIFIED: NO

Provenance & Taxonomy

OrganismCorvus brachyrhynchos [Animal]

FamilyBPI/LBP

Tax ID85066

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria