Peptide Database

Peptide NameChymopapain

Function Ontology

Therapeutic / Biomedical activity ▸ Enzyme replacement therapy

Standard StatusStandard

Sequence Length352 amino acids

Chemical FormulaC1774H2698N460O529S15

DescriptionStandard

        MATMSSISKIIFLATCLIIHMGLSSADFYTVGYSQDDLTSIERLIQLFDSWMLKHNKIYESIDEKIYRFEIFRDNLMYIDETNKKNNSYWLGLNGFADLSNDEFKKKYVGFVAEDFTGLEHFDNEDFTYKHVTNYPQSIDWRAKGAVTPVKNQGACGSCWAFSTIATVEGINKIVTGNLLELSEQELVDCDKHSYGCKGGYQTTSLQYVANNGVHTSKVYPYQAKQYKCRATDKPGPKVKITGYKRVPSNCETSFLGALANQPLSVLVEAGGKPFQLYKSGVFDGPCGTKLDHAVTAVGYGTSDGKNYIIIKNSWGPNWGEKGYMRLKRQSGNSQGTCGVYKSSYYPFKGFA
    

Molecular Weight39414.14 Da

Isoelectric Point (pI)8.39

Net Charge (pH 7.0)4.03

Net Charge (pH 7.4) 3.21

Charge Density (pH 7.0) 0.0115

GRAVY Index-0.40

Hydrophobic Moment 0.70

Boman Index0.03

Instability Index23.74

Aliphatic Index 70.62

Aromaticity 0.1307

Extinction Coeff. Reduced 67270.00

Extinction Coeff. Oxidized 67770.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0410026 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

FamilyEnzyme

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Enzyme replacement

Half-LifeFollowing intra-discal injection, the level of chymopapain decreases gradually and presents a half-life of 2-3 days. The half-life for urinary excretion is reported to be of about 3 days.[A32704]