Peptide Database

Peptide NameCrotalicidin (Ctn) (Cathelicidin-related antimicrobial peptide) (CRAMP) (Vipericidin)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Antiparasitic ▸ General antiparasitic ▸ Antiparasitic

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length194 amino acids

Chemical FormulaC989H1539N249O304S7

DescriptionStandard

        MQGFFWKTWLVLAVCGTPASLAHRPLSYGEALELAVSVYNGKAGEASLYRLLEAVPQPEWDPSSEGSQQLNFTLKETACQVEEERSLEECGFQEDGVVLECTGYYFFGETPPVVVLSCVPVGGVEEEEEEEEEEQKAEAENDEEVEKEKGDEEKDQPKRVKRFKKFFKKVKKSVKKRLKKIFKKPMVIGVTIPF
    

Molecular Weight22005.74 Da

Isoelectric Point (pI)4.85

Net Charge (pH 7.0)-11.39

Net Charge (pH 7.4) -11.83

Charge Density (pH 7.0) -0.0587

GRAVY Index-0.55

Hydrophobic Moment 0.89

Boman Index-0.06

Instability Index56.14

Aliphatic Index 71.75

Aromaticity 0.0979

Extinction Coeff. Reduced 23950.00

Extinction Coeff. Oxidized 24200.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 8913.25

LogP -99.45

H-bond Donors 303.0

H-bond Acceptors 301.0

Rotatable Bonds 705.0

Heavy Atoms 1549.0

Ring Count 34.0

Amide Bonds 204.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0060175 VERIFIED: YES

Provenance & Taxonomy

OrganismCrotalus durissus terrificus [Animal]

FamilyCathelicidin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal Antiparasitic Anti-Gram-negative Anti-Gram-positive Hemolytic

TargetStaphylococcus aureus

RECORD: Rec_0070665 VERIFIED: YES

Provenance & Taxonomy

OrganismCrotalus durissus terrificus [Animal]

FamilyCathelicidin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal Antiparasitic Anti-Gram-negative Anti-Gram-positive Hemolytic

TargetStreptococcus pyogenes

RECORD: Rec_0292562 VERIFIED: YES

Provenance & Taxonomy

OrganismCrotalus durissus cascavella [Animal]

FamilyCathelicidin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Anti-Gram-positive Hemolytic

TargetGram-negative and Gram-positive bacteria

RECORD: Rec_0308750 VERIFIED: YES

Provenance & Taxonomy

OrganismCrotalus durissus terrificus [Animal]

FamilyCathelicidin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal Antiparasitic Anti-Gram-negative Anti-Gram-positive Hemolytic

TargetPseudomonas aeruginosa

RECORD: Rec_0337688 VERIFIED: YES

Provenance & Taxonomy

OrganismCrotalus durissus terrificus [Animal]

FamilyCathelicidin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal Antiparasitic Anti-Gram-negative Anti-Gram-positive Hemolytic

TargetTrypanosoma cruzi

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