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MYP_003924
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Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
not Standard
23 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
GIGKFKHSAKKFGKAXVGEXXNS
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0098700 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
stereochemistry not specified [Other]
Contains X placeholder residue(s)
Bio-Activity Profile
Antimicrobial
PaperPatent US 10464975 B2 Evidence URLhttps://patents.google.com/patent/US10464975B2/en PatentUS 10464975 B2
RECORD: Rec_0237955 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
side-chain hydrocarbon-stapled peptide [Cyclic]
modified/noncanonical residue-containing peptide [Modified]
S5 stapling amino acid at 16,20; norleucine at 21; S5 stapling amino acid; norleucine; Hydrocarbon staple / ring-closing metathesis constraint
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Bacillus cereus ATCC 14579
>50 μg/mL
MIC
PMID31427820 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31427820/
RECORD: Rec_0292288 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
side-chain hydrocarbon-stapled peptide [Cyclic]
modified/noncanonical residue-containing peptide [Modified]
S5 stapling amino acid at 16,20; norleucine at 21; S5 stapling amino acid; norleucine; Hydrocarbon staple / ring-closing metathesis constraint
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 25923
>50 μg/mL
MIC
PMID31427820 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31427820/
RECORD: Rec_0315477 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
side-chain hydrocarbon-stapled peptide [Cyclic]
modified/noncanonical residue-containing peptide [Modified]
S5 stapling amino acid at 16,20; norleucine at 21; S5 stapling amino acid; norleucine; Hydrocarbon staple / ring-closing metathesis constraint
Bio-Activity Profile
Hemolytic
human red blood cells
1.7 %
Hemolysis
PMID31427820 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31427820/
RECORD: Rec_0355285 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
side-chain hydrocarbon-stapled peptide [Cyclic]
modified/noncanonical residue-containing peptide [Modified]
S5 stapling amino acid at 16,20; norleucine at 21; S5 stapling amino acid; norleucine; Hydrocarbon staple / ring-closing metathesis constraint
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa ATCC 27853
17.68 μg/mL
MIC
PMID31427820 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31427820/
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