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MYP_003881
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Basic Information
Sarcotoxin-1C
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
39 amino acids
C184H314N62O52
Standard
Sequence
GWLRKIGKKIERVGQHTRDATIQVLGIAQQAANVAATAR
Physicochemical Analysis
4226.85 Da
11.57
4.85
4.59
0.1243
-0.29
0.99
-0.08
22.46
100.26
0.0256
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1889.99
-20.72
67.0
58.0
146.0
298.0
3.0
43.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0027858 VERIFIED: YES
Provenance & Taxonomy
Sarcophaga peregrina [Animal]
Cecropin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
PMID3888997 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3888997/
RECORD: Rec_0052049 VERIFIED: YES
Provenance & Taxonomy
Sarcophaga peregrina [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0098241 VERIFIED: YES
Provenance & Taxonomy
Flesh fly [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperPrimary structure of sarcotoxin I, an antibacterial protein induced in the hemolymph of Sarcophaga peregrina (flesh fly) larvae.
RECORD: Rec_0227411 VERIFIED: NO
Provenance & Taxonomy
Sarcophaga peregrina,Boettcherisca peregrina [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
Gram negative bacteria
RECORD: Rec_0321219 VERIFIED: YES
Provenance & Taxonomy
Flesh fly [Animal]; Insecta [Animal]
33208; 50557
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID3888997 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3888997/
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