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MYP_003828
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Basic Information
Nigrosin-OG21 (Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Immunology ▸ Adverse immune reactivity ▸ Histamine-release modulation
Immunology ▸ Innate immune modulation ▸ Mast cell modulation
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
21 amino acids
C87H157N23O24S2
Standard
Sequence
GLLSGVLGVGKKVLCGLSGLC
Physicochemical Analysis
1973.45 Da
8.90
1.74
1.50
0.0828
1.36
0.45
0.46
-2.60
152.86
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
737.82
-6.77
28.0
28.0
68.0
136.0
0.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0031784 VERIFIED: YES
Provenance & Taxonomy
Odorrana grahami [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
15-21
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
rabbit red blood cells at 50 μg/ml
PaperAnti-infection peptidomics of amphibian skin. Mol Cell Proteomics. 2007 May;6(5):882-94. doi: 10.1074/mcp.M600334-MCP200. PMID: 17272268. PMID17272268 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17272268/
RECORD: Rec_0032966 VERIFIED: YES
Provenance & Taxonomy
Odorrana margaretae [Animal]
Nigrocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
15-21
Bio-Activity Profile
Antimicrobial
Escherichia coli ATCC 25922
8-16 μg/mL
MIC
PaperAssociating biological activity and predicted structure of antimicrobial peptides from amphibians and insects
RECORD: Rec_0060185 VERIFIED: YES
Provenance & Taxonomy
Odorrana grahami [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0068348 VERIFIED: NO
Provenance & Taxonomy
Rana grahami,Huia grahami [Animal]; Odorrana margaratae [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0069693 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Human erythrocytes
50 μg/mL
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/17272268/ PMID17272268 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17272268/
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