Peptide Database

Peptide NameCorticotropin

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Standard StatusStandard

Sequence Length39 amino acids

Chemical FormulaC210H314N56O57S

DescriptionStandard

        SYSMEHFRWGKPVGKKRRPVKVYPDGAEDQLAEAFPLEF
    

Molecular Weight4567.15 Da

Isoelectric Point (pI)8.09

Net Charge (pH 7.0)0.55

Net Charge (pH 7.4) 0.28

Charge Density (pH 7.0) 0.0142

GRAVY Index-0.86

Hydrophobic Moment 0.63

Boman Index-0.14

Instability Index50.66

Aliphatic Index 50.00

Aromaticity 0.1538

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1816.02

LogP -13.11

H-bond Donors 62.0

H-bond Acceptors 60.0

Rotatable Bonds 146.0

Heavy Atoms 324.0

Ring Count 12.0

Amide Bonds 39.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0178641 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyACTH analog

Tax ID9606

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Diagnostic

Half-Life15 min (IV adminstration)

PaperPubMed-linked source references: PMID:18801471; PMID:19697885; PMID:1310274; PMID:27593282; PMID:25897773; PMID:25064382; PMID:24521933; PMID:24318839; PMID:22342285 PMID18801471;19697885;1310274;27593282;25897773;25064382;24521933;24318839;22342285 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18801471/

RECORD: Rec_0184230 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

FamilyEnzyme

Structure & Mods

Configcyclic peptide scaffold [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Immunomodulatory Hormone replacement Diagnostic

TargetCHO

Half-Life15 minutes (IV adminstration)