MYP_003629
P21L9
Antimicrobial
Antiviral
▸
Antiviral mechanism
▸
Membrane / Ion-channel modulation
▸
Sodium channel modulation
▸
Sodium channel inhibitor
not Standard
21 amino acids
-
contains X representing unresolved or non-standard residue
LDLTYEMLSLQQVVXALNXSY
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Amino Acid Composition
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0043130
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The 'X' at position 15 and 19 are S5((S)-pentenyl alanine)
Bio-Activity Profile
Anti-MERS-CoV
Fusion inhibition
MERS-CoV S protein-mediated cell-cell fusion; Huh-7 cells
10.9±1.0 μM
EC50 (MERS-CoV S protein-mediated cell-cell fusion assay)
RECORD: Rec_0047703
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The 'X' at position 15 and 19 are S5((S)-pentenyl alanine)
Bio-Activity Profile
Anti-MERS-CoV
Fusion inhibition
MERS-CoV S protein-mediated cell-cell fusion; Huh-7 cells
10.9±1.0 μM
EC50 (MERS-CoV S protein-mediated cell-cell fusion assay)
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
RECORD: Rec_0080747
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
①The 'X' (position: 15 and 19) in sequence indicates S5 stapling amino acid. Note: S5 is (S)-pentenyl alanine. ②X (15) and X (19) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anti-MERS-CoV
Fusion inhibition
MERS-CoV S protein-mediated cell-cell fusion; Huh-7 cells
14.1±2.3 μM
EC50 (MERS-CoV S protein-mediated cell-cell fusion assay)
RECORD: Rec_0143915
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
unspecified non-canonical residue at 15,19
Bio-Activity Profile
Anti-MERS-CoV
Fusion inhibition
MERS-CoV S protein-mediated cell-cell fusion; Huh-7 cells
cell-cell fusion inhibition assay
RECORD: Rec_0346682
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
side-chain cyclized peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
①The 'X' (position: 15 and 19) in sequence indicates S5 stapling amino acid. Note: S5 is (S)-pentenyl alanine. ②X (15) and X (19) are cross-linked by hydrocarbon stapling.
Bio-Activity Profile
Anti-MERS-CoV
Fusion inhibition
MERS-CoV S protein-mediated cell-cell fusion; Huh-7 cells
14.1±2.3 μM
EC50 (MERS-CoV S protein-mediated cell-cell fusion assay)
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min