Peptide Database

Peptide NameAntagonist G [Arg6, D-Trp7,9, MePhe8] - substance P (6-11)

Function Ontology

Anticancer

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC111H158N28O20S2

DescriptionStandard

        RWFWLMRPKPQQFFGLM
    

Molecular Weight2268.75 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)2.76

Net Charge (pH 7.4) 2.55

Charge Density (pH 7.0) 0.1623

GRAVY Index-0.32

Hydrophobic Moment 0.29

Boman Index0.06

Instability Index71.05

Aliphatic Index 45.88

Aromaticity 0.2941

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 778.92

LogP -0.24

H-bond Donors 27.0

H-bond Acceptors 25.0

Rotatable Bonds 69.0

Heavy Atoms 161.0

Ring Count 9.0

Amide Bonds 18.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0012761 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilySubstance P

Structure & Mods

Configlinear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

N-TermNone

C-TermNone

Other ModsMethylation of phenylalanine at 3rd position

Bio-Activity Profile

Function

Anticancer

MethodRP-HPLC and Electrochemical Detection

Half-LifeHuman plasma, in vitro; 15840 s