Peptide Database

Peptide NamePituitary adenylate cyclase-activating polypeptide 38

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Metabolic

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length33 amino acids

Chemical FormulaC176H279N51O48S

DescriptionStandard

        HSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQ
    

Molecular Weight3909.48 Da

Isoelectric Point (pI)10.09

Net Charge (pH 7.0)5.84

Net Charge (pH 7.4) 5.57

Charge Density (pH 7.0) 0.1770

GRAVY Index-0.87

Hydrophobic Moment 0.44

Boman Index-0.25

Instability Index33.60

Aliphatic Index 62.12

Aromaticity 0.1515

Extinction Coeff. Reduced 5960.00

Extinction Coeff. Oxidized 5960.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1661.62

LogP -15.29

H-bond Donors 61.0

H-bond Acceptors 56.0

Rotatable Bonds 134.0

Heavy Atoms 276.0

Ring Count 6.0

Amide Bonds 34.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0139449 VERIFIED: NO

Provenance & Taxonomy

OrganismHeloderma suspectum [Animal]

FamilyPituitary adenylate cyclase-activating polypeptide

Tax ID8554

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other Mods27:Leucine amide

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Growth regulation Development regulation Receptor modulation

Half-LifeMammalian: 3.5 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0356513 VERIFIED: NO

Provenance & Taxonomy

OrganismHeloderma suspectum [Animal]

FamilyPituitary adenylate cyclase-activating polypeptide

Tax ID8554

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other Mods27:Leucine amide

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Growth regulation Development regulation Receptor modulation

Targetits receptor activates G proteins and stimulates adenylate cyclase in pituitary cell

Half-LifeMammalian: 3.5 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0411018 VERIFIED: NO

Provenance & Taxonomy

OrganismHeloderma suspectum [Animal]

FamilyGlucagon

Tax ID8554

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsLeu27 Amidation

Bio-Activity Profile

Function

Hormone Metabolic