Peptide Database

Peptide NameSLAY-screened peptide P2308

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC62H95N19O19

DescriptionStandard

        PPYRSSVSRFTN
    

Molecular Weight1410.53 Da

Isoelectric Point (pI)10.84

Net Charge (pH 7.0)1.96

Net Charge (pH 7.4) 1.90

Charge Density (pH 7.0) 0.1631

GRAVY Index-1.09

Hydrophobic Moment 0.44

Boman Index-0.30

Instability Index67.32

Aliphatic Index 24.17

Aromaticity 0.1667

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 628.68

LogP -8.73

H-bond Donors 24.0

H-bond Acceptors 21.0

Rotatable Bonds 41.0

Heavy Atoms 100.0

Ring Count 4.0

Amide Bonds 12.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0020705 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/