Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length464 amino acids

Chemical FormulaC2324H3704N606O642S14

DescriptionStandard

        MAVRMVVRSLALAALMLAACMVLARATNPGFVARITEKGLDYARQEGIAALEKKLAKLKLPDFSGSFKVKPFGNVHYEFYSLDLRSFQLPSSQIVPVPNVGLRVSVSKAFAHLTGKWKVKKRFIKDHGSFDLKVEGISISIGLKLGSDASGRPTVTTSECSTQISNVRIHISGRFGWLYKLFHKKIESSFRKTMESKVCEEVTSSVSTQLQPYLQTLPVTTKIDNVAGIDYSLGEFFSLAHRLPAPFPPPALAFPTEHDRMVYLGASSYFFNTAGFVYQTAGVLVFNITDDMVPKGVEFHLNTSTFSAFIPKLEKLYPDRLMKLQVMTSSAPSLTITPGGLSLMPVVDIQAYAILSNSSLAPLFLLSLTSNISATVAVNSSRIGGTLALGRLKLSLKHSDVGPFSVQLLQSLMNIYGSKILLPRLNERLKAGFPLPLPDRIKLSSILLQPHQNFLLLAADVHYG
    

Molecular Weight50854.85 Da

Isoelectric Point (pI)9.74

Net Charge (pH 7.0)19.45

Net Charge (pH 7.4) 18.53

Charge Density (pH 7.0) 0.0419

GRAVY Index0.17

Hydrophobic Moment 0.71

Boman Index0.14

Instability Index41.16

Aliphatic Index 102.54

Aromaticity 0.0905

Extinction Coeff. Reduced 30370.00

Extinction Coeff. Oxidized 30495.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0212104 VERIFIED: YES

Provenance & Taxonomy

OrganismAlligator mississippiensis [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria