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MYP_003330
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Basic Information
Varv E
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
29 amino acids
C117H187N35O40S6
Standard
Sequence
GLPICGETCVGGTCNTPGCSCSWPVCTRN
Physicochemical Analysis
2916.34 Da
5.96
-0.30
-0.59
-0.0102
0.16
0.26
0.16
39.95
46.90
0.0345
5500.00
5875.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1174.30
-18.26
46.0
46.0
85.0
198.0
5.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0203542 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]
Defensin
97415
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization (N termini to C termini)
Cyclization (C termini to N termini)
5-19, 9-21, 14-26
Disulfide bonds between Cys5 and Cys19; Cys9 and Cys21; Cys14 and Cys26.
Bio-Activity Profile
Antiviral Anti-HIV Entry inhibition
HIV
0.35 μM
EC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperCyclotides as natural anti-HIV agents. | Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. | Biopolymers. 2008;90(1):51-60. | DOI:10.1002/bip.20886 | PMID:18008336 PMID18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18008336/
RECORD: Rec_0209335 VERIFIED: YES
Provenance & Taxonomy
Viola tricolor [Plant]; Viola arvensis [Plant]; Viola baoshanensis [Plant]; Viola yedoensis [Plant]; Viola tianshanica [Plant]; Viola abyssinica [Plant]; Viola philippica [Plant]
Cyclotide
214053, 349688, 39648
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antiviral Anticancer Cytotoxic Nematocidal Anthelmintic Anti-HIV
Human lung carcinoma A549
10 μg/mL
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola tricolor | PubMed PMID 14987040 PMID14987040;20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14987040/
RECORD: Rec_0212965 VERIFIED: NO
Provenance & Taxonomy
Viola arvensis [Plant]
Cyclotide
Structure & Mods
backbone-cyclized cyclotide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperVarv peptide E Evidence URLhttps://www.uniprot.org/uniprotkb/P83835/entry
RECORD: Rec_0237987 VERIFIED: YES
Provenance & Taxonomy
Viola baoshanensis [Plant]
Cyclotide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0262348 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]
Defensin
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
5-19; 9-21; 14-26
Bio-Activity Profile
Anticancer Antiviral
HIV inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells
0.35 μM
EC50
PaperCyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. | PubMed PMID: 10075760 | PubMed PMID: 14987049 | PubMed PMID: 20580652 PMID18008336;10075760;14987049;20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18008336/
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