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MYP_003330
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Basic Information
Varv E
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
29 amino acids
C117H187N35O40S6
Standard
Sequence
GLPICGETCVGGTCNTPGCSCSWPVCTRN
Physicochemical Analysis
2916.34 Da
5.96
-0.30
-0.59
-0.0102
0.16
0.26
0.16
39.95
46.90
0.0345
5500.00
5875.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1174.30
-18.26
46.0
46.0
85.0
198.0
5.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0045015 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]
Defensin
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
5-19; 9-21; 14-26
Bio-Activity Profile
Anticancer Antiviral Cytotoxic
CEM-SS cells
3.98 μM
IC50
PaperCyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. | PubMed PMID: 10075760 | PubMed PMID: 14987049 | PubMed PMID: 20580652 PMID18008336;10075760;14987049;20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18008336/
RECORD: Rec_0072395 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
RECORD: Rec_0096952 VERIFIED: YES
Provenance & Taxonomy
Viola tricolor [Plant]; Viola arvensis [Plant]; Viola baoshanensis [Plant]; Viola yedoensis [Plant]; Viola tianshanica [Plant]; Viola abyssinica [Plant]; Viola philippica [Plant]
Cyclotide
214053, 349688, 39648
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antiviral Anticancer Cytotoxic Nematocidal Anthelmintic Anti-HIV
Human hepatocarcinoma BEL-7402
10 μg/mL
IC50
PaperIsolation and characterization of cytotoxic cyclotides from Viola tricolor | PubMed PMID 14987040 PMID14987040;20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14987040/
RECORD: Rec_0103576 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]
Defensin
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
5-19; 9-21; 14-26
Bio-Activity Profile
Anticancer Antiviral Hemolytic
human type O red blood cells
PaperCyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. | PubMed PMID: 10075760 | PubMed PMID: 14987049 | PubMed PMID: 20580652 PMID18008336;10075760;14987049;20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18008336/
RECORD: Rec_0104284 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]
Defensin
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
5-19; 9-21; 14-26
Bio-Activity Profile
Anticancer Antiviral
PaperCyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. | PubMed PMID: 10075760 | PubMed PMID: 14987049 | PubMed PMID: 20580652 PMID18008336;10075760;14987049;20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18008336/
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