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MYP_003257
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Basic Information
Tachystatin-B1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
42 amino acids
C214H319N67O56S6
Standard
Sequence
YVSCLFRGARCRVYSGRSCCFGYYCRRDFPGSIFGTCSRRNF
Physicochemical Analysis
4918.63 Da
9.61
6.70
6.40
0.1595
-0.21
0.60
-0.15
67.40
34.76
0.2143
5960.00
6335.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2025.52
-23.25
84.0
69.0
154.0
343.0
10.0
42.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0205261 VERIFIED: YES
Provenance & Taxonomy
Tachypleus tridentatus [Animal]
Tachystatin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
PaperHorseshoe crab hemocyte-derived antimicrobial polypeptides, tachystatins, with sequence similarity to spider neurotoxins.
RECORD: Rec_0301171 VERIFIED: YES
Provenance & Taxonomy
Tachypleus tridentatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
4-20; 11-25; 19-37
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Host defense
PaperPDB 2DCV structural record; NMR; chain A; residues 1-42
RECORD: Rec_0321032 VERIFIED: YES
Provenance & Taxonomy
Tachypleus tridentatus [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal
Staphylococcus aureus
7.4 μg/mL
IC50
PaperPubMed PMID: 10473569 | PubMed PMID: 17394123 PMID10473569;17394123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10473569/
RECORD: Rec_0323769 VERIFIED: YES
Provenance & Taxonomy
Tachypleus tridentatus [Animal]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0327805 VERIFIED: YES
Provenance & Taxonomy
Tachypleus tridentatus [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal
Candida albicans
3 μg/mL
IC50
PaperPubMed PMID: 10473569 | PubMed PMID: 17394123 PMID10473569;17394123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10473569/
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