Peptide Database

Peptide NameBrevinin-1VLd (Frogs, amphibians, animals)

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length24 amino acids

Chemical FormulaC126H204N28O27S2

DescriptionStandard

        FLPLIAGVAANFLPKIFCLISKKC
    

Molecular Weight2607.27 Da

Isoelectric Point (pI)9.39

Net Charge (pH 7.0)2.74

Net Charge (pH 7.4) 2.50

Charge Density (pH 7.0) 0.1141

GRAVY Index1.34

Hydrophobic Moment 0.57

Boman Index0.45

Instability Index23.86

Aliphatic Index 138.33

Aromaticity 0.1250

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 856.42

LogP -1.93

H-bond Donors 30.0

H-bond Acceptors 32.0

Rotatable Bonds 83.0

Heavy Atoms 183.0

Ring Count 5.0

Amide Bonds 24.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0223477 VERIFIED: YES

Provenance & Taxonomy

OrganismRana vaillanti [Animal]

FamilyBrevinin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermCyclization

Disulfide18-24

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Cytotoxic

RECORD: Rec_0224121 VERIFIED: YES

Provenance & Taxonomy

OrganismLithobates vaillanti [Animal]

FamilyBrevinin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Hemolytic Anticancer

Targeterythrocytes

Activity5-6 μM

MethodLC50

RECORD: Rec_0279785 VERIFIED: YES

Provenance & Taxonomy

OrganismLithobates vaillanti [Animal]

FamilyBrevinin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetCandida albicans

Activity3000 μM

MethodMIC

RECORD: Rec_0279942 VERIFIED: YES

Provenance & Taxonomy

OrganismRana vaillanti [Animal]

FamilyBrevinin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermCyclization

Disulfide18-24

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic

Targethuman erythrocytes

Activity5000 μM

MethodLC50

RECORD: Rec_0280833 VERIFIED: YES

Provenance & Taxonomy

OrganismLithobates vaillanti [Animal]

FamilyBrevinin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Hemolytic Anticancer Anti-Gram-positive

TargetStaphylococcus aureus

Activity3 μM

MethodMIC

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