MYP_003240
Colistin
Antimicrobial
Antiparasitic
▸
General antiparasitic
▸
Antiparasitic
Standard
10 amino acids
C56H110N16O13
Standard
KTKKKLLKKT
1215.57 Da
10.70
5.75
5.54
0.5754
-1.72
0.50
-0.70
-7.98
78.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
521.80
-3.61
19.0
19.0
49.0
85.0
0.0
9.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0337756
VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
RECORD: Rec_0361219
VERIFIED: YES
Provenance & Taxonomy
Paenibacillus polymyxa var [Bacterium]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Lipidation
Warning: the sequence is a close mimic of the natural peptide antibiotic. In the natural form, there are multiple Dab (2,4-diaminobutanoic acid), which are represented here as lysines. The molecule is cyclic due to the formation of an amide bond between the amino group of Dab in position 4 and the carboxyl group of the C-terminus. Residue Leu6 is a D-amino acid and the N-terminus is attached by a fatty acid (Polymyxin E1= colistin A: fatty acid A=6-methyloctanoic acid; Polymyxin E2=colistin B: fatty acid B=6-methylheptanoic acid)
Bio-Activity Profile
Antimicrobial
Antiparasitic
Acinetobacter baumannii or 18 Acinetobacter spp. isolates
<1 μg/mL
MIC50
RECORD: Rec_0400821
VERIFIED: YES
Provenance & Taxonomy
Paenibacillus polymyxa var [Bacterium]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Lipidation
Warning: the sequence is a close mimic of the natural peptide antibiotic. In the natural form, there are multiple Dab (2,4-diaminobutanoic acid), which are represented here as lysines. The molecule is cyclic due to the formation of an amide bond between the amino group of Dab in position 4 and the carboxyl group of the C-terminus. Residue Leu6 is a D-amino acid and the N-terminus is attached by a fatty acid (Polymyxin E1= colistin A: fatty acid A=6-methyloctanoic acid; Polymyxin E2=colistin B: fatty acid B=6-methylheptanoic acid)
Bio-Activity Profile
Antimicrobial
Antiparasitic
16 Klebsiella pneumoniae strains
<1 μg/mL
MIC50
Showing 3 records on this page · Page 2 of 2