Peptide Database

Peptide NameSLAY-screened peptide P886

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC75H126N22O22S

DescriptionStandard

        PQAEISYSLCILRAR
    

Molecular Weight1720.00 Da

Isoelectric Point (pI)8.64

Net Charge (pH 7.0)0.95

Net Charge (pH 7.4) 0.88

Charge Density (pH 7.0) 0.0634

GRAVY Index0.15

Hydrophobic Moment 0.25

Boman Index-0.01

Instability Index60.69

Aliphatic Index 117.33

Aromaticity 0.0667

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 721.61

LogP -6.65

H-bond Donors 28.0

H-bond Acceptors 24.0

Rotatable Bonds 56.0

Heavy Atoms 120.0

Ring Count 2.0

Amide Bonds 15.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0289077 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/