Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length464 amino acids

Chemical FormulaC2283H3657N581O659S17

DescriptionStandard

        MFLCCWLGLVALIPTTLSTNPGVKVRLTEKGIEYGRQLGMAVIQQKLRSIKIPDFSGTEEVSPIGKVQYSLSNMHIVNVGLPKSSVDLVPGTGVTLSIGDAFISLNGNWRVKYLRIIKDSGSFDLNVNGLSIATTISIKSDETGRPAVSTASCSATVGSAKVKFHGGASWLYNLFTTFIDKALRNALQKQICPLVADAVSDLNPQLKTLNVLAKVDKYAEIEYSMVSSPTVLKSSIDLSLKGEFYNIGKHQEPPFSPAAFNLPPQNNNMLYIGMSAFTVNSAAFVYNNAGVLSLSVTDDMIPKSSPIRLNTKTFGAFIPQIAKQFPGLMMKLLVKTVKIPTLTFEPNNATVQATTTVTAFAIQTNSTLSPLFVLNLEASVSARMFVSEMKLAAAVTLNKMDLTLAKSYVGDFQVGPLENVFQGVLKWVVIPTVNGELILTLNSKEDFSPKVPKRISICIFSIWQ
    

Molecular Weight50333.06 Da

Isoelectric Point (pI)9.28

Net Charge (pH 7.0)10.73

Net Charge (pH 7.4) 10.19

Charge Density (pH 7.0) 0.0231

GRAVY Index0.21

Hydrophobic Moment 0.72

Boman Index0.17

Instability Index32.59

Aliphatic Index 102.28

Aromaticity 0.0819

Extinction Coeff. Reduced 42400.00

Extinction Coeff. Oxidized 42650.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0243005 VERIFIED: NO

Provenance & Taxonomy

OrganismOreochromis aureus (Israeli tilapia) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria