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MYP_003154
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Basic Information
Unnamed
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
11 amino acids
C89H111N17O12
Standard
Sequence
FLWWLFKWAWK
Physicochemical Analysis
1610.94 Da
10.00
1.76
1.55
0.1598
0.33
0.43
0.49
14.51
80.00
0.5455
22000.00
22000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
469.52
6.00
18.0
14.0
45.0
118.0
10.0
10.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0365767 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Cytotoxic
SK-OV-3
14.58 μM
IC50
PaperAnticancer activity of undecapeptide analogues derived from antimicrobial peptide, brevinin-1EMa PMID22644847 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22644847/
RECORD: Rec_0369726 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Gaegurin/Brevinin analogs
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Antimicrobial
HCT-116 (colon cancer)
14.8 μM
IC50
PaperAnticancer activity of undecapeptide analogues derived from antimicrobial peptide, brevinin-1EMa | https://pubmed.ncbi.nlm.nih.gov/22644847/ PMID22644847 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22644847/
RECORD: Rec_0381396 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin-derived
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Amidation
Bio-Activity Profile
Anticancer
HCT-116
14.8 μM
IC50
PaperApplication Value of Antimicrobial Peptides in Gastrointestinal Tumors PMID38069041 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/38069041/
RECORD: Rec_0409528 VERIFIED: NO
Provenance & Taxonomy
Glandirana rugosa [Animal]
Gaegurin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Cytotoxic
MKN-45
13770 μM
IC50
PaperAnalogues of antimicrobial and anticancer peptide synthesized and produced from Gaegurin 5 Evidence URLhttps://patents.google.com/patent/US8076284B2/en PatentUS8076284B2
RECORD: Rec_0418800 VERIFIED: NO
Provenance & Taxonomy
Glandirana rugosa [Animal]
Gaegurin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Cytotoxic
SK-OV-3
14580 μM
IC50
PaperNovel analogues of antimicrobial and anticancer peptide synthesized and produced from gaegurin 5 Evidence URLhttps://patents.google.com/patent/WO2007133033A1/en PatentWO2007133033A1
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