Peptide Database

Peptide NameUnnamed

Function Ontology

Therapeutic / Biomedical activity ▸ Dermatology / Cosmetic bioactivity ▸ Skin aging modulation ▸ Anti-aging

Therapeutic / Biomedical activity ▸ Dermatology / Cosmetic bioactivity ▸ Skin aging modulation ▸ Collagen boosting

Standard StatusStandard

Sequence Length6 amino acids

Chemical FormulaC41H56N12O7

DescriptionStandard

        LHWFRA
    

Molecular Weight828.96 Da

Isoelectric Point (pI)9.76

Net Charge (pH 7.0)0.85

Net Charge (pH 7.4) 0.59

Charge Density (pH 7.0) 0.1412

GRAVY Index-0.03

Hydrophobic Moment 0.54

Boman Index0.12

Instability Index3.53

Aliphatic Index 81.67

Aromaticity 0.3333

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 315.19

LogP 0.08

H-bond Donors 12.0

H-bond Acceptors 9.0

Rotatable Bonds 23.0

Heavy Atoms 60.0

Ring Count 4.0

Amide Bonds 5.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0136819 VERIFIED: NO

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHexapeptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Anti-aging Collagen boosting Anti-melanogenic

RECORD: Rec_0343902 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHexapeptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Anti-aging Collagen boosting Anti-melanogenic

Targetprimary human epidermal keratinocytes (HEKa)

MethodqRT-PCR gene-expression assay at 0.1 mg/mL

RECORD: Rec_0401500 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHexapeptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Anti-melanogenic Skin brightening

Targetprimary human epidermal melanocytes (HEMn)

Activity49.3 % decrease in melanin

Methodmelanin content assay at 0.1 mg/mL

RECORD: Rec_0431389 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Other ModsN-terminal acetylation; C-terminal amidation

Bio-Activity Profile

Function

Tyrosinase inhibitory Anti-melanogenic Skin brightening

Targetrecombinant mushroom tyrosinase

Activity30.6 % inhibition

Methodtyrosinase inhibition assay at 0.5 mg/mL

RECORD: Rec_0431390 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Other ModsN-terminal acetylation; C-terminal amidation

Bio-Activity Profile

Function

Tyrosinase inhibitory Anti-melanogenic Skin brightening

Targetrecombinant mushroom tyrosinase

Activity58.1 % inhibition

Methodtyrosinase inhibition assay at 1 mg/mL