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MYP_003090
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Basic Information
WR7 (Derived from leucocin A)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
18 amino acids
C93H159N43O19
Standard
Sequence
WGRAFRRGVRRLARGGRR
Physicochemical Analysis
2183.53 Da
12.00
7.76
7.56
0.4311
-1.34
1.10
-0.72
96.57
48.89
0.1111
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1069.01
-12.02
44.0
27.0
74.0
155.0
3.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0044462 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Bacteriocin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Escherichia coli O157:H7 CICC 21530
58.64 μM
MIC
PMID28002968 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28002968/
RECORD: Rec_0057559 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli 35150
29.32 μM
MIC
PaperInsights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles PMID28002968 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28002968/
RECORD: Rec_0079296 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Bacteriocin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Escherichia coli O157:H7 CICC 21530
7.33 μM
MIC
PMID28002968 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28002968/
RECORD: Rec_0083147 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Bacteriocin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Pseudomonas fluorescens CICC 21620
29.32 μM
MIC
PMID28002968 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28002968/
RECORD: Rec_0091077 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Cytotoxic
cells induced by WR7 is 97
PaperInsights into the Antimicrobial Activity and Cytotoxicity of Engineered α-Helical Peptide Amphiphiles PMID28002968 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28002968/
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