Peptide Database

Peptide NameLEDGF 361-370[K364A]

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition

Standard StatusStandard

Sequence Length11 amino acids

Chemical FormulaC56H86N14O19

DescriptionStandard

        WNSLAIDNLDV
    

Molecular Weight1259.36 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-2.24

Net Charge (pH 7.4) -2.44

Charge Density (pH 7.0) -0.2034

GRAVY Index0.22

Hydrophobic Moment 0.20

Boman Index0.22

Instability Index20.31

Aliphatic Index 141.82

Aromaticity 0.0909

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 551.12

LogP -4.52

H-bond Donors 18.0

H-bond Acceptors 17.0

Rotatable Bonds 39.0

Heavy Atoms 89.0

Ring Count 2.0

Amide Bonds 12.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0178347 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Integrase inhibition

TargetHIV-1

Activity0.1 μM

Method% inhibition

Half-LifeMammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min

PaperMechanism of action of the HIV-1 integrase inhibitory peptide LEDGF 361-370. | Hayouka Z, Levin A, Maes M, Hadas E, Shalev DE, Volsky DJ, Loyter A, Friedler A. | Biochem Biophys Res Commun. 2010 Apr 2;394(2):260-5. | DOI:10.1016/j.bbrc.2010.02.100 | PMID:20171172 PMID20171172 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20171172/

RECORD: Rec_0363508 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetHIV-1

RECORD: Rec_0383808 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral

TargetHIV-1[60-70% IN activity = 19.5 microM