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MYP_003020
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Basic Information
Unnamed
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Renin inhibition ▸ Renin inhibitory
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Standard
4 amino acids
C20H37N7O5
Standard
Sequence
RALP
Physicochemical Analysis
455.55 Da
9.75
0.76
0.56
0.1900
-0.12
0.89
-0.18
55.65
122.50
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
203.73
-1.31
7.0
6.0
12.0
32.0
1.0
3.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0049858 VERIFIED: YES
Provenance & Taxonomy
Brassica napus [Plant]
ACE-inhibitory peptide
3708
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
ACE
650 μM
IC50
PaperGlycinyl-Histidinyl-Serine (GHS), a Novel Rapeseed Protein-Derived Peptide Has Blood Pressure-Lowering Effect in Spontaneously Hypertensive Rats PMID23919612 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23919612/
RECORD: Rec_0056228 VERIFIED: YES
Provenance & Taxonomy
Brassica napus [Plant]
ACE-inhibitory peptide
3708
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
ACE
970 μM
IC50
PaperGlycinyl-Histidinyl-Serine (GHS), a Novel Rapeseed Protein-Derived Peptide Has Blood Pressure-Lowering Effect in Spontaneously Hypertensive Rats PMID23919612 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23919612/
RECORD: Rec_0072062 VERIFIED: YES
Provenance & Taxonomy
Brassica napus [Plant]
ACE-inhibitory peptide
3708
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
Spontaneously hypertensive rat (SHR)
16 mmHg
SBP decrease
PaperGlycinyl-Histidinyl-Serine (GHS), a Novel Rapeseed Protein-Derived Peptide Has Blood Pressure-Lowering Effect in Spontaneously Hypertensive Rats PMID23919612 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23919612/
RECORD: Rec_0156684 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
Angiotensin-converting enzyme (ACE)
650.0
IC50
PaperHe R., Malomo S. A., Alashi A., Girgih A. T., Ju X., Aluko R. E.. Purification and hypotensive activity of rapeseed protein derived renin and angiotensin converting enzyme inhibitory peptides. J. Funct. Foods, 5, 781-789, 2013.
RECORD: Rec_0275165 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive Renin inhibitory
Renin
970.0
IC50
PaperHe R., Malomo S. A., Alashi A., Girgih A. T., Ju X., Aluko R. E.. Purification and hypotensive activity of rapeseed protein derived renin and angiotensin converting enzyme inhibitory peptides. J. Funct. Foods, 5, 781-789, 2013.
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