Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length181 amino acids

Chemical FormulaC881H1426N238O274S8

DescriptionStandard

        MASLCPQVEKMYPDRPMKLKVSAASAPFLNITPGKLSLTPDVDIQAYAILEDSSLAPLFLLSMRSTISTNITMSSTKITGSLQLGKMQLTLKHSDVGPFSVQLLQSIMNFFAANVLIPQVNGESPGREQGRDSQREGLSWEEALLPGLLGGEETGDGWRKRLRETQNWERELTVEKTELDI
    

Molecular Weight19992.70 Da

Isoelectric Point (pI)5.12

Net Charge (pH 7.0)-4.39

Net Charge (pH 7.4) -4.71

Charge Density (pH 7.0) -0.0242

GRAVY Index-0.25

Hydrophobic Moment 0.67

Boman Index0.02

Instability Index49.95

Aliphatic Index 91.60

Aromaticity 0.0552

Extinction Coeff. Reduced 19480.00

Extinction Coeff. Oxidized 19480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 8229.36

LogP -97.73

H-bond Donors 282.0

H-bond Acceptors 279.0

Rotatable Bonds 672.0

Heavy Atoms 1401.0

Ring Count 25.0

Amide Bonds 196.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0169239 VERIFIED: NO

Provenance & Taxonomy

OrganismSphenodon punctatus [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence