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MYP_002928
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Basic Information
Gaegurin 6 (4-24), GGN6 (4-24)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
21 amino acids
C105H174N24O26S2
Standard
Sequence
LLAGLAANFLPTIICKISYKC
Physicochemical Analysis
2252.78 Da
8.86
1.74
1.50
0.0827
1.23
0.50
0.42
7.50
144.29
0.0952
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
792.35
-3.83
29.0
30.0
72.0
157.0
3.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0314433 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Gaegurin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Cytotoxic
Human embryonic kidney HEK293T cells
>100 μg/mL
IC50
PMID14499271 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14499271/
RECORD: Rec_0366301 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Gaegurin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer Cytotoxic
Human prostate adenocarcinoma PC-3
100 μg/mL
IC50
PMID14499271 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14499271/
RECORD: Rec_0388988 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
MCF-7
100 μg/mL
IC50
PaperPubMed PMID: 14499271 PMID14499271 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14499271/
RECORD: Rec_0399273 VERIFIED: YES
Provenance & Taxonomy
Glandirana rugosa [Animal]
Gaegurin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
15-21
Bio-Activity Profile
Anticancer Cytotoxic
A-549
>100 μg/mL
IC50
PaperIn vitro activities of native and designed peptide antibiotics against drug sensitive and resistant tumor cell lines PMID14499271 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14499271/
RECORD: Rec_0424702 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Gaegurin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer Cytotoxic
Human hepatocellular carcinoma Hep 3B
100 μg/mL
IC50
PMID14499271 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14499271/
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