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MYP_002924
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Basic Information
Indolicidin (2-13)[R12P][R13P]
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Standard
12 amino acids
C92H110N18O13
Standard
Sequence
LPWKWPWWPWPP
Physicochemical Analysis
1675.97 Da
8.75
0.76
0.55
0.0633
-1.05
0.14
0.35
34.07
32.50
0.4167
27500.00
27500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
444.44
6.06
14.0
14.0
34.0
123.0
15.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0047869 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
inhibition of strand transfer catalyzed by integrase
215 μM
IC50
PaperPubMed PMID: 15482931 PMID15482931 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15482931/
RECORD: Rec_0091481 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:Inhibition of 3′-processing catalyzed by integrase
185 μM
IC50
PaperPubMed PMID: 15482931 PMID15482931 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15482931/
RECORD: Rec_0250417 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-HIV-1 Replication inhibition
HIV-1
185 μM
IC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperSynthesis and HIV-1 integrase inhibitory activity of dimeric and tetrameric analogs of indolicidin. | Krajewski K, Marchand C, Long YQ, Pommier Y, Roller PP. | Bioorg Med Chem Lett. 2004 Nov 15;14(22):5595-8. | DOI:10.1016/j.bmcl.2004.08.061 | PMID:15482931 PMID15482931 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15482931/
RECORD: Rec_0333311 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 15482931 PMID15482931 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15482931/
RECORD: Rec_0391290 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Replication inhibition
inhibition of strand transfer catalyzed by integrase
215 μM
IC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperSynthesis and HIV-1 integrase inhibitory activity of dimeric and tetrameric analogs of indolicidin. | Krajewski K, Marchand C, Long YQ, Pommier Y, Roller PP. | Bioorg Med Chem Lett. 2004 Nov 15;14(22):5595-8. | DOI:10.1016/j.bmcl.2004.08.061 | PMID:15482931 PMID15482931 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15482931/