Peptide Database

Peptide NameT21N23

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard StatusStandard

Sequence Length46 amino acids

Chemical FormulaC249H417N79O68

DescriptionStandard

        RIQQIEQKIHHIEQRIQQIEQRAIEAQQHLLQLTVWGIKQLQARIL
    

Molecular Weight5605.46 Da

Isoelectric Point (pI)9.97

Net Charge (pH 7.0)2.03

Net Charge (pH 7.4) 1.67

Charge Density (pH 7.0) 0.0441

GRAVY Index-0.53

Hydrophobic Moment 0.64

Boman Index-0.12

Instability Index101.06

Aliphatic Index 131.52

Aromaticity 0.0217

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2460.80

LogP -19.83

H-bond Donors 82.0

H-bond Acceptors 73.0

Rotatable Bonds 201.0

Heavy Atoms 396.0

Ring Count 5.0

Amide Bonds 57.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0071410 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral

TargetHIV-1

RECORD: Rec_0178458 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermNone

DisulfideDisulfide bond(s) reported

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetHIV-1(human immunodeficiency virus 1):inhiition of cell-cell fusion between TZM-bl cells and HL2/3 cells

Activity0.0389±0.0358 μM

MethodIC50

RECORD: Rec_0291782 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Fusion inhibition

TargetHIV-1 (human immunodeficiency virus 1) | TZM-bl cells; HL2/3 cells

Activity0.0389±0.0358 μM

MethodIC50

Half-LifeMammalian: 1 h; Yeast: 2 min; E. coli: 2 min

PaperSuitable fusion of N-terminal heptad repeats to achieve covalently stabilized potent N-peptide inhibitors of HIV-1 infection. | Lai W, Wang C, Yan J, Liu H, Zhang W, Lin B, Xi Z. | Bioorg Med Chem. 2020 Feb 15;28(4):115214. | DOI:10.1016/j.bmc.2019.115214 | PMID:31932193 PMID31932193 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31932193/