Peptide Database

Peptide NameLactoferrampin

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antifungal

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC114H188N32O32

DescriptionStandard

        EDLIWKLLSKAQEKFGKNKSR
    

Molecular Weight2518.91 Da

Isoelectric Point (pI)9.82

Net Charge (pH 7.0)2.84

Net Charge (pH 7.4) 2.66

Charge Density (pH 7.0) 0.1350

GRAVY Index-1.14

Hydrophobic Moment 0.58

Boman Index-0.32

Instability Index40.23

Aliphatic Index 79.05

Aromaticity 0.0952

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1091.65

LogP -8.87

H-bond Donors 38.0

H-bond Acceptors 35.0

Rotatable Bonds 92.0

Heavy Atoms 178.0

Ring Count 3.0

Amide Bonds 22.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0328977 VERIFIED: YES

Provenance & Taxonomy

OrganismBos taurus [Animal]

FamilyLactoferrampin

Tax ID9913

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal

TargetCandida albicans

MethodColony inhibition assay

PaperLactoferrampin, an antimicrobial peptide of bovine lactoferrin, exerts its candidacidal activity by a cluster of positively charged residues at the C-terminus in combination with a helix-facilitating N-terminal part | Van Der Kraan, MIA. et al. | DOI: 10.1515/BC.2005.017 Evidence URLhttps://www.uniprot.org/uniprotkb/P24627/entry