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MYP_002734
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Basic Information
Unnamed
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza A ▸ Anti-Influenza A virus
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
11 amino acids
C48H71N15O20
Standard
Sequence
NGESSADWAKN
Physicochemical Analysis
1178.17 Da
4.37
-1.24
-1.44
-0.1125
-1.56
0.32
-0.23
2.21
18.18
0.0909
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
597.37
-9.15
20.0
19.0
38.0
83.0
2.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0339077 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferrin-derived peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-Influenza A virus Replication inhibition
Influenza A virus (A/Roma-ISS/2/08 H1N1) | MDCK cells
0.000000225±0.0000000058 μM
EC50
Mammalian: 1.4 h; Yeast: 3 min; E. coli: >10 h
PaperBovine lactoferrin-derived peptides as novel broad-spectrum inhibitors of influenza virus. | Ammendolia MG, Agamennone M, Pietrantoni A, Lannutti F, Siciliano RA, De Giulio B, Amici C, Superti F. | Pathog Glob Health. 2012 Mar;106(1):12-9. | DOI:10.1179/2047773212Y.0000000004 | PMID:22595270 PMID22595270 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22595270/
RECORD: Rec_0411642 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Influenza A virus (A/Roma-ISS/2/08 H1N1):inhibition of viral replication in MDCK cells
EC50
PaperPubMed PMID: 22595270 PMID22595270 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22595270/
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