Peptide Database

Peptide NameDermadistinctin-K (DD K; Frogs, amphibians, animals)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Antiparasitic ▸ Antiprotozoal

Antiparasitic ▸ General antiparasitic ▸ Antiparasitic

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Standard StatusStandard

Sequence Length33 amino acids

Chemical FormulaC140H239N41O41

DescriptionStandard

        GLWSKIKAAGKEAAKAAAKAAGKAALNAVSEAV
    

Molecular Weight3152.65 Da

Isoelectric Point (pI)10.00

Net Charge (pH 7.0)3.76

Net Charge (pH 7.4) 3.54

Charge Density (pH 7.0) 0.1139

GRAVY Index0.19

Hydrophobic Moment 0.56

Boman Index0.13

Instability Index12.42

Aliphatic Index 92.42

Aromaticity 0.0303

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1324.58

LogP -14.40

H-bond Donors 46.0

H-bond Acceptors 45.0

Rotatable Bonds 109.0

Heavy Atoms 222.0

Ring Count 2.0

Amide Bonds 33.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0300504 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa distincta [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiprotozoal

TargetEnterococcus faecalis

Activity19 μM

MethodMIC

RECORD: Rec_0320955 VERIFIED: YES

Provenance & Taxonomy

OrganismPhasmahyla jandaia [Animal]

FamilyDermaseptin

Structure & Mods

Configribosomal mature linear peptide [Linear]

ChiralityGene-encoded natural peptide composed of standard L-amino acids [L]

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-negative

TargetEscherichia coli

Activity0.6 μM

MethodMIC

RECORD: Rec_0337317 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa distincta [Animal]

FamilyDermaseptin

Structure & Mods

ConfigSingle-chain peptide backbone represented as a linear sequence entry [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetPseudomonas aeruginosa

RECORD: Rec_0352841 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa distincta [Animal]

FamilyDermaseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal Anti-Candida Antiparasitic Antiprotozoal Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetStaphylococcus aureus

RECORD: Rec_0361707 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa distincta [Animal]

FamilyDermaseptin

Structure & Mods

ConfigSingle-chain peptide backbone represented as a linear sequence entry [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetCandida albicans ATCC 1023

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