Peptide Database

Peptide NameDermadistinctin-K (DD K; Frogs, amphibians, animals)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Antiparasitic ▸ Antiprotozoal

Antiparasitic ▸ General antiparasitic ▸ Antiparasitic

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Toxic

Standard StatusStandard

Sequence Length33 amino acids

Chemical FormulaC140H239N41O41

DescriptionStandard

        GLWSKIKAAGKEAAKAAAKAAGKAALNAVSEAV
    

Molecular Weight3152.65 Da

Isoelectric Point (pI)10.00

Net Charge (pH 7.0)3.76

Net Charge (pH 7.4) 3.54

Charge Density (pH 7.0) 0.1139

GRAVY Index0.19

Hydrophobic Moment 0.56

Boman Index0.13

Instability Index12.42

Aliphatic Index 92.42

Aromaticity 0.0303

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1324.58

LogP -14.40

H-bond Donors 46.0

H-bond Acceptors 45.0

Rotatable Bonds 109.0

Heavy Atoms 222.0

Ring Count 2.0

Amide Bonds 33.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0025468 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa distincta [Animal]

FamilyDermaseptin

Structure & Mods

ConfigSingle-chain peptide backbone represented as a linear sequence entry [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetCandida tropicalis

Activity10.1 μM

MethodMIC

RECORD: Rec_0035958 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa distincta [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiprotozoal

TargetPseudomonas aeruginosa

Activity2.4 μM

MethodMIC

RECORD: Rec_0044187 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa distincta [Animal]

FamilyDermaseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antiparasitic

TargetPseudomonas aeruginosa

Activity2.4 μM

MethodMIC

RECORD: Rec_0045413 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa distincta [Animal]

FamilyDermaseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal Anti-Candida Antiparasitic Antiprotozoal Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetCandida albicans

Activity20.3 μM

MethodMIC

RECORD: Rec_0082368 VERIFIED: YES

Provenance & Taxonomy

OrganismPhyllomedusa distincta [Animal]

FamilyDermaseptin

Structure & Mods

ConfigSingle-chain peptide backbone represented as a linear sequence entry [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetStaphylococcus aureus

Activity4.7 μM

MethodMIC

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