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MYP_002732
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Basic Information
Dermadistinctin-K (DD K; Frogs, amphibians, animals)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
33 amino acids
C140H239N41O41
Standard
Sequence
GLWSKIKAAGKEAAKAAAKAAGKAALNAVSEAV
Physicochemical Analysis
3152.65 Da
10.00
3.76
3.54
0.1139
0.19
0.56
0.13
12.42
92.42
0.0303
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1324.58
-14.40
46.0
45.0
109.0
222.0
2.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0005444 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa distincta [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiprotozoal
Escherichia coli
0.6 μM
MIC
PMID10477123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10477123/
RECORD: Rec_0006010 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa distincta [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiprotozoal
Candida guilliermondii
20.3 μM
MIC
PMID10477123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10477123/
RECORD: Rec_0006857 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa distincta [Animal]
Dermaseptin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Candida albicans
PMID10477123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10477123/
RECORD: Rec_0010164 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa distincta [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Antiprotozoal
Candida albicans ATCC 1023
10.1 μM
MIC
PMID10477123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10477123/
RECORD: Rec_0022809 VERIFIED: YES
Provenance & Taxonomy
Phasmahyla jandaia [Animal]
Dermaseptin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
4.7 μM
MIC
PaperC.V. Batista et al. / Peptides 20 (1999) 679-686. Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta Evidence URLhttps://www.uniprot.org/uniprotkb/P86639/entry
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