Peptide Database

Peptide NameSLAY-screened peptide P3820

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length10 amino acids

Chemical FormulaC56H83N13O14S

DescriptionStandard

        CVLQHAFYTL
    

Molecular Weight1194.40 Da

Isoelectric Point (pI)6.73

Net Charge (pH 7.0)-0.16

Net Charge (pH 7.4) -0.43

Charge Density (pH 7.0) -0.0164

GRAVY Index1.02

Hydrophobic Moment 0.35

Boman Index0.43

Instability Index58.17

Aliphatic Index 117.00

Aromaticity 0.2000

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 437.45

LogP -1.74

H-bond Donors 16.0

H-bond Acceptors 16.0

Rotatable Bonds 35.0

Heavy Atoms 84.0

Ring Count 3.0

Amide Bonds 10.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0262102 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/