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MYP_002664
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Basic Information
Halictine-2/11, HAL-2/11
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
12 amino acids
C70H118N18O14
Standard
Sequence
GKWLSLLKHILK
Physicochemical Analysis
1435.80 Da
10.30
2.84
2.59
0.2370
0.23
0.65
0.15
50.89
162.50
0.0833
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
526.18
-0.34
19.0
18.0
50.0
102.0
3.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0291658 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer Cytotoxic
Human cervical carcinoma HeLa
2.0
IC50
PMID30240951 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30240951/
RECORD: Rec_0309420 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
RECORD: Rec_0328782 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Pseudomonas aeruginosa
31.7 μM
MIC
PMID30240951 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30240951/
RECORD: Rec_0356949 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Cytotoxic
Human umbilical vein endothelial cells HUVEC
21.6±2.4 μM
IC50
PMID30240951 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30240951/
RECORD: Rec_0380796 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
SW480
40 μM
IC50
PaperToxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells. Peptides. 2012 Jan;33(1):18-26. doi: 10.1016/j.peptides.2011.11.002. PMID: 22100226. PMID22100226 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22100226/
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