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MYP_002624
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Basic Information
ISHP2
Anticancer
Standard
12 amino acids
C67H96N22O16
Standard
Sequence
ARRKAFSHWYSG
Physicochemical Analysis
1465.62 Da
11.00
2.88
2.64
0.2401
-1.16
0.25
-0.28
54.50
16.67
0.2500
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
638.40
-6.08
25.0
20.0
45.0
105.0
5.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0119667 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
FITC, 5(6)-carboxy fluorescence
None
Stapled: Ⓧ(7) and Ⓧ (11) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
MCF-7
3.71±0.21 μM
IC50
PaperAdak A, Das G, Gupta V, Khan J, Mukherjee N, Mondal P, Roy R, Barman S, Gharai PK, Ghosh S. Evolution of Potential Antimitotic Stapled Peptides from Multiple Helical Peptide Stretches of the Tubulin Heterodimer Interface: Helix-Mimicking Stapled Peptide Tubulin Inhibitors. J Med Chem. 2022 Oct 27;65(20):13866-13891. PMID36240440 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/36240440/
RECORD: Rec_0301436 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
FITC, 5(6)-carboxy fluorescence
None
Stapled: Ⓧ(7) and Ⓧ (11) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
MCF-7
52.33±3.75 μM
IC50
PaperAdak A, Das G, Gupta V, Khan J, Mukherjee N, Mondal P, Roy R, Barman S, Gharai PK, Ghosh S. Evolution of Potential Antimitotic Stapled Peptides from Multiple Helical Peptide Stretches of the Tubulin Heterodimer Interface: Helix-Mimicking Stapled Peptide Tubulin Inhibitors. J Med Chem. 2022 Oct 27;65(20):13866-13890. PMID36240440 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/36240440/
RECORD: Rec_0339280 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
FITC, 5(6)-carboxy fluorescence
None
Stapled: Ⓧ(7) and Ⓧ (11) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
MCF-7
18.69±1.27 μM
IC50
PaperAdak A, Das G, Gupta V, Khan J, Mukherjee N, Mondal P, Roy R, Barman S, Gharai PK, Ghosh S. Evolution of Potential Antimitotic Stapled Peptides from Multiple Helical Peptide Stretches of the Tubulin Heterodimer Interface: Helix-Mimicking Stapled Peptide Tubulin Inhibitors. J Med Chem. 2022 Oct 27;65(20):13866-13888. PMID36240440 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/36240440/
RECORD: Rec_0374031 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
FITC, 5(6)-carboxy fluorescence
None
Stapled: Ⓧ(7) and Ⓧ (11) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
MCF-7
33.79±2.34 μM
IC50
PaperAdak A, Das G, Gupta V, Khan J, Mukherjee N, Mondal P, Roy R, Barman S, Gharai PK, Ghosh S. Evolution of Potential Antimitotic Stapled Peptides from Multiple Helical Peptide Stretches of the Tubulin Heterodimer Interface: Helix-Mimicking Stapled Peptide Tubulin Inhibitors. J Med Chem. 2022 Oct 27;65(20):13866-13888. PMID36240440 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/36240440/