Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length153 amino acids

Chemical FormulaC789H1286N202O207S6

DescriptionStandard

        MQHYTKSHPVRMKLMVTAAPVLRLQNNSFTIEIPCFVVVSALLSNSMIKPIFAVNTSIGLKANAVIAKQKLIVLLQLQRLYLSLTYSSIGSFQVQRLKNFLSYSLQNTVIPPIAAALKRGLQLPTMAKLFFSEAVTKVNKGYILISTDLNYKF
    

Molecular Weight17106.27 Da

Isoelectric Point (pI)10.30

Net Charge (pH 7.0)13.65

Net Charge (pH 7.4) 13.29

Charge Density (pH 7.0) 0.0892

GRAVY Index0.40

Hydrophobic Moment 0.57

Boman Index0.18

Instability Index32.00

Aliphatic Index 119.15

Aromaticity 0.0915

Extinction Coeff. Reduced 8940.00

Extinction Coeff. Oxidized 8940.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 6578.28

LogP -55.42

H-bond Donors 227.0

H-bond Acceptors 229.0

Rotatable Bonds 571.0

Heavy Atoms 1204.0

Ring Count 23.0

Amide Bonds 170.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0183388 VERIFIED: NO

Provenance & Taxonomy

OrganismMicrurus corallinus [Animal]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence