Peptide Database

Peptide NameTransferrin receptor (TfR)-lytic hybrid peptide

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length32 amino acids

Chemical FormulaC179H303N47O35S

DescriptionStandard

        THRPPMWSPVWPGGGKLLLKLLKKLLKLLKKK
    

Molecular Weight3705.68 Da

Isoelectric Point (pI)11.51

Net Charge (pH 7.0)8.48

Net Charge (pH 7.4) 8.22

Charge Density (pH 7.0) 0.2649

GRAVY Index-0.30

Hydrophobic Moment 0.84

Boman Index-0.01

Instability Index22.95

Aliphatic Index 118.75

Aromaticity 0.0625

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1301.04

LogP -2.75

H-bond Donors 45.0

H-bond Acceptors 46.0

Rotatable Bonds 125.0

Heavy Atoms 262.0

Ring Count 9.0

Amide Bonds 31.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0403422 VERIFIED: YES

Provenance & Taxonomy

OrganismMusca domestica [Animal]

FamilyTransferrin receptor-targeting peptide

Tax ID7370

Structure & Mods

Configlinear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Anticancer

TargetSK-BR-3

Activity6.5 μM

MethodIC50

RECORD: Rec_0412098 VERIFIED: YES