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MYP_002499
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Basic Information
Transferrin receptor (TfR)-lytic hybrid peptide
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
32 amino acids
C179H303N47O35S
Standard
Sequence
THRPPMWSPVWPGGGKLLLKLLKKLLKLLKKK
Physicochemical Analysis
3705.68 Da
11.51
8.48
8.22
0.2649
-0.30
0.84
-0.01
22.95
118.75
0.0625
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1301.04
-2.75
45.0
46.0
125.0
262.0
9.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0078596 VERIFIED: YES
Provenance & Taxonomy
Musca domestica [Animal]
Transferrin receptor-targeting peptide
7370
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
None
Bio-Activity Profile
Anticancer Cytotoxic
MDA-MB-231
7.8 μM
IC50
PMID21849092 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21849092/
RECORD: Rec_0115566 VERIFIED: YES
Provenance & Taxonomy
Musca domestica [Animal]
Transferrin receptor-targeting peptide
7370
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
None
Bio-Activity Profile
Anticancer
SF-295
6.3 μM
IC50
PMID21849092 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21849092/
RECORD: Rec_0116981 VERIFIED: YES
Provenance & Taxonomy
Musca domestica [Animal]
Transferrin receptor-targeting peptide
7370
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
None
Bio-Activity Profile
Anticancer
COLO-587
6.4 μM
IC50
PMID21849092 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21849092/
RECORD: Rec_0130842 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
None
Bio-Activity Profile
Anticancer
Mouse erythrocytes
100 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/23328867/ PMID23328867 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23328867/
RECORD: Rec_0150765 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
Evidence URLhttps://patents.google.com/patent/US20110319336A1/en PatentUS 2011/0319336 A1
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